The draw was conducted after obtained 10 clubs that won the play-off, 10 clubs will be joined by 22 clubs already assured of a place in the group ranked in the league each European country of 2015-16 season.
In each group, teams play against each other home-and-away in a round-robin format. The group winners and runners-up advance to the round of 16, while the third-placed teams enter the 2016–17 UEFA Europa League round of 32.
The winners of the 2016–17 UEFA Champions League will qualify as the UEFA representative at the 2017 FIFA Club World Cup in the United Arab Emirates, and also earn the right to play against the winners of the 2016–17 UEFA Europa League in the 2017 UEFA Super Cup.
| Grup A | Grup B | Grup C | Grup D |
|---|---|---|---|
| Klub 1 | Klub 1 | Klub 1 | Klub 1 |
| Klub 2 | Klub 2 | Klub 2 | Klub 2 |
| Klub 3 | Klub 3 | Klub 3 | Klub 3 |
| Klub 4 | Klub 4 | Klub 4 | Klub 4 |
| Grup E | Grup F | Grup G | Grup H |
| Klub 1 | Klub 1 | Klub 1 | Klub 1 |
| Klub 2 | Klub 2 | Klub 2 | Klub 2 |
| Klub 3 | Klub 3 | Klub 3 | Klub 3 |
| Klub 4 | Klub 4 | Klub 4 | Klub 4 |